Advances in polymer science develop several novel drug delivery systems. Especially biodegradable polyesters have been employed for drug delivery system because of their biocompatibility and biodegradability. They provide controlled release of drugs in constant doses over long periods of time and release of both hydrophilic and hydrophobic drugs as well as reduce drug degradation and drug loss, prevent harmful side effects. Among biodegradable polyesters, lactide/glycolide polyesters have been used widely in biomedical applications like fracture repair, surgical dressings and controlled drug delivery. This review highlights the synthesis processes of biodegradable polyesters like PLA, PGA and PLGA, their main researches and developments in controlled drug delivery systems.
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